Cimetidine and Gastric pH

The effectiveness of cimetidine as a preoperative medication in increasing gastric pH and decreasing gastric volume in obese patients.

The obese patient presenting for surgery is at high risk for developing the pulmonary acid aspiration syndrome due to a large volume of acidic gastric contents. Cimetidine, an H 2 receptor antagonist, reduces gastric secretion and increases gastric pH. In the following study, cimetidine increased gastric pH in the obese patient, but had no effect on gastric volume. By increasing gastric pH, cim...

Cimetidine for ulcers recurring after gastric surgery.

The effects of cimetidine and ranitidine with and without metoclopramide on gastric volume and pH in morbidly obese patients.

The efficacy of preanaesthetic intravenous cimetidine versus ranitidine with and without metoclopramide for acid aspiration prophylaxis was assessed in 60 morbidly obese patients in a double-blind manner. Group 1 patients received cimetidine 300 mg + saline. Group 2 patients received cimetidine 300 mg + metoclopramide 10 mg. Group 3 patients received ranitidine 100 mg + saline. Group 4 patients...

Effect of bedtime ranitidine on overnight gastric acid output and intragastric pH: dose/response study and comparison with cimetidine.

A dose/response study has been carried out in seven patients with endoscopically proven duodenal ulcers in symptomatic remission, measuring intragastric pH and gastric acid output overnight after a bedtime dose of ranitidine (75 mg, 150 mg, and 300 mg); and the results have been compared with placebo and with bedtime cimetidine 400 mg. The currently recommended ranitidine maintenance dose (150 ...

Ultrastructural changes in gastric ulcers after bicitropeptide and cimetidine treatment.

Ultrastructural studies were conducted on biopsy specimens taken by endoscopy from the edge of gastric ulcers in the distal part of the stomach of 9 patients before and after treatment with either bicitropeptide or cimetidine. Marked depletion of mucin granules in the mucous epithelial cells and the pyloric gland cells was found in all patients and there was morphological evidence of a block in...